Most incarnations of Sherlock Holmes are rather dour. Sherlock is a tortured, nearly anti-social genius. "Ms. Holmes & Ms. Watson" touches upon these traits, Holmes has her trademark savant deductive-reasoning skills fully intact. She has an affinity for marijuana, as well, subbing for the usual cocaine habit, both meant to dull Sherlock's incessant deductions when they become bothersome. What's brand new in "Ms. Holmes, (other than the obvious gender-switch,) is her manic energy. It took some getting used to, but it eventually became the best part of the show. To call Ashley Song's performance "animated" is both apt and inadequate. Her "Sherlock" is kind of like what Inspector Clouseau may have been, had he been competent.
I believe there's a classic piece of acting-advice: "to play to the back of the House," and does she ever. (Opening-Night was packed, and I had to sit Rear-Orchestra. I've sat there before, when the demands of the set required it, but I'm accustomed to front-row.) Thus, I can attest to the veracity of my previous statement. On that note, while the sightline was decent, the amplification of the dialogue wqas sorely lacking. I hope they can increase the volume.
"Ms.. Holmes" is not quite a parody, (there's too much affection for the source-material to fit that designation.) But, it is far more of a romp than is typical. If you're in the mood for a healthy dose of comedy with your Arthur Conan Doyle, this is for you.